These days it would have to be a reality TV person (I refuse to call them stars) that woke up one morning and everyone was gone except the cameraperson who is deaf and dumb and refuses to communicate by notes since his one hand is holding the camera. The reality show person starts a search and finds one dead body after the next. Some hanging from the ceiling, some chopped into bits and dribbled into the Kitchen drawers, etc. They have left cryptic clues that can't be understood by anything human.....
I had thought about writing this and I would call it CHILDREN OF THE VIRUS. Remember the sickness going around the American Southwest a few years ago? Mice were carrying a deadly virus in their crap. If you swept it up and inhaled it y6ou caught virus.
This could be a Young Adult genre. A Church group from all over the world has a camp out. Nine young teenagers discovered an unused cabin while being blindsided by an unsuspected snow storm. They take shelter in the cabin, sweep it up and inhale a deadly virus.
They are given a experimental drug to save their lives but it also increases brain activity. They find that they can easily persuade others to buy cars, invest, etc, etc. Some become Operatives others criminals.
Use this situation to your advantage, and write a comedy about a writer who can't think of any ideas for his new book. You could make some great humorous scenes from that idea, heck it could even be a one act play!
So you didn't like the kill all the reality shows idea. Hmmm...Perhaps:
An American girl falls for a young man who was born in India, lived in Oman as a child, then in Canada as a teenager before his parents moved the family to Maryland. The young man, now 24, asks the girl if he can teach her to play golf. The driving range is their first date. Does the young man eventually marry her? I hope so I want my basement back.